Long-term infection-acquired immunity against the SARS-CoV-2 Delta variant in a hamster model
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HIGHLIGHTSoHuman vaccinee serum neutralizing titers are reduced against SARS-CoV-2 Delta
oSimilar results are obtained with serum from previously infected hamsters
oPrior infection with an early isolate protects hamsters from reinfection with Delta
oPrior infection of hamsters prevents Delta transmission to na?ve hamsters
SUMMARYThe emergence of the SARS-CoV-2 Delta variant (B.1.617.2) raises concerns about potential reduced sensitivity of the virus to antibody neutralization and subsequent vaccine breakthrough infections. Here, we use a live virus neutralization assay with sera from Pfizer- and Moderna-vaccinated individuals to examine neutralizing antibody titers against SARS-CoV-2 and observe a 3.9- and 2.7-fold reduction, respectively, in neutralizing antibody titers against the Delta variant compared with an early isolate bearing only a D614G substitution in its spike protein. We observe similar reduced sensitivity with sera from hamsters that were previously infected with an early isolate of SARS-CoV-2. Despite this reduction in neutralizing antibody titers against the Delta variant, hamsters previously infected (up to 15 months earlier) with an early isolate are protected from infection with the Delta variant, suggesting that the immune response to the first infection is sufficient to provide protection against subsequent infection with the Delta variant.
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